AXonomIX - Axonomics: identifing the translational networks altered in motor neuron diseases
The idea behind the AXonomIX project is to provide a comprehensive and unbiased map of translational activities taking place in different cellular and subcellular compartments of the MN and motor unit, separated by a range of available techniques both in terms of composition and structure. The map will be obtained in tissues and cells from wild type mice, mouse models of MN degeneration and established mouse models of distinct MN diseases sharing mutations of RBPs or proteins involved in translation. Subsequent comparisons between the generated profiles will be instrumental in identifying common mechanisms underlying the stability of MNs in health and disease. The project has been purposefully structured to span from basic knowledge to the identification of potential new drug targets and preliminary screening for the identification of candidate molecules capable of affecting translation or axon growth.
AXonomIX Consortium Partner 1 - Project Coordinator: Università degli Studi di Trento – Centre for Integrative di Biology (CIBio) - Alessandro Quattrone
Partner 2 - Scientist in charge: Consiglio Nazionale delle Ricerche - Istituto di Biofisica di Trento (CNR-IBF TN) - Gabriella Viero
Partner 3 - Scientist in charge: Fondazione Bruno Kessler (FBK) - Cecilia Pederzolli
Partner 4 - Scientist in charge: Università degli Studi di Padova Dipartimento di Scienze Biomediche e Consiglio Nazionale delle Ricerche Istituto di Neuroscienze - Cesare Montecucco
Partner 5 - Scientist in charge: University of Edinburgh (UK) College of Medicine & Veterinary Medicine - Thomas Henry Gillingwater